What is the Dengue NS1 Test?

Frequently Asked Questions:

Why do I need the Dengue NS1 Test?

The NS1 test should be performed on the first day of a fever's onset. It's still relevant after 24 hours, but it's best if you take it right away. Because the quantity of IgG in the blood tends to grow slowly, the test is used to detect infection in the latter stages of the disease. The amount usually rises six to ten days after infection, and antibodies can stay in the blood for up to 90 days or the remainder of your life.

What happens during the Dengue NS1 Test?

During the test, the doctor or physician discharges the blood from the vein through the needle. This process may be a bit painful while collecting the blood. After collecting the needed blood, disperse in a heparinized tube or any vials.

What is the difference between dengue NS1 and IgM?

The rate of NS1 detection is inversely related to IgG antibodies, but the rate of IgM detection is directly proportional. The NS1/IgM, the sensitivity, and specificity for identifying acute dengue infection were 88.65 percent and 98.75 percent, respectively. The test is susceptible and specific. The Dengue Antigen NS1, IgG, and IgM tests identify fever, mainly if it occurs after a trip to a tropical or subtropical location.

What is the average value of the NS1 antigen?

The amount of NS1 Ag in acute-phase serum samples ranges from 0.5-2 g/ml to less than 0.04 g/ml in convalescent-phase serum. The necessity of matched sera, which is required in the convalescent phase if the early stages are negative, also complicates prognosis. This NS1 Ag test can diagnose dengue disease in the acute phase of primary and secondary dengue infection.

Is dengue NS1 severe?

In our group, NS1 antigen positivity was linked to a greater chance of suffering severe symptoms in our group, especially when higher after day illness. While more research is needed, the test might be a warning indication of severe dengue.

What does dengue NS1 positive mean?

A positive NS1 test indicates dengue virus infection but does not reveal the serotype. A negative NS1 test result does not rule out the absence of illness. People who have a negative NS1 test should be tested for dengue IgM antibodies to see if they have recently been exposed to the virus. A positive DENV test indicates that the NS1 antigen is detectable 1 to 2 days after infection and up to 9 days after symptom onset.

Can NS1 be a false negative?

Yes, it can be a false negative. In dengue serotypes 2 and 4, false-negative NS1 tests have been recorded. In secondary dengue, NS1 tests have also been less sensitive. It should also be mentioned that in many tropical countries, the diagnosis of dengue fever is frequently made based on suspicion rather than scientific confirmation. This means that dengue diagnosis might be both false-positive and false-negative.

Is the dengue NS1 test accurate?

Yes, the dengue NS1 test is the most accurate for prediction. Thus, The NS1 antigen fast test has a high level of accuracy, with a sensitivity of 55 percent to 82 percent and a specificity of 97 percent to 100 percent. The NS1 test can be carried out within five days of the beginning of the fever since it is designed to identify dengue NS1 antigen.

What is the normal range for the Dengue NS1 ELISA test?

The normal range for the Dengue NS1 ELISA test is typically reported as non-reactive or negative. A non-reactive result indicates the absence of the NS1 antigen in the blood, suggesting no active dengue infection at the time of testing. However, it's essential to interpret the results in the context of the individual's symptoms, medical history, and other diagnostic tests to ensure accurate diagnosis and appropriate management.