Metastatic Neuroblastoma is an advanced form of a rare childhood cancer that originates in immature nerve cells of the sympathetic nervous system, typically in the adrenal glands, neck, chest, or spine. The exact cause of neuroblastoma is not well understood, but it is linked to genetic mutations that occur in early nerve cells. This cancer often spreads (metastasizes) to other parts of the body, such as the bones, liver, and skin. Symptoms vary depending on the tumor’s location and spread but can include a lump or mass, bone pain, fatigue, fever, and weight loss. Diagnosis involves imaging tests such as CT scans, MRIs, or MIBG scans, blood and urine tests, and biopsy of the tumor tissue. Genetic testing may also be conducted to identify specific mutations.
Treatment is complex and aggressive, often requiring a combination of therapies. Initially, high-dose chemotherapy is used to shrink the tumors, followed by surgical removal of the primary tumor. In some cases, high-dose chemotherapy is accompanied by stem cell transplant to restore bone marrow cells destroyed by the treatment. Radiation therapy along with immunotherapy, is often incorporated to improve survival rates. Continuous follow-up care is essential to monitor for recurrence and manage long-term side effects of the treatment.
Harsha Vardhith from Kadapa successfully received treatment for Metastatic Neuroblastoma at Yashoda Hospitals, Hyderabad, under the supervision of Dr. Harish Kancharla, Sr. Consultant Medical Oncologist and Hemato-Oncologist and Dr. Madhav Danthala, Consultant Hemato-Oncologist and Bone Marrow Transplant Physician.